REACTION MECHANISM BETWEEN ε-AMINOCAPROIC ACID AND PLASMIN, TISSUE ACTIVATOR AND TRYPSIN
نویسندگان
چکیده
منابع مشابه
The mechanism of the reaction between human plasminogen-activator inhibitor 1 and tissue plasminogen activator.
The structural events taking place during the reaction between PAI-1 (plasminogen-activator inhibitor 1) and the plasminogen activators sc-tPA (single-chain tissue plasminogen activator) and tc-tPA (two-chain tissue plasminogen activator) were studied. Complexes were formed by mixing sc-tPA or tc-tPA with PAI-1 in slight excess (on an activity basis). The complexes were purified from excess PAI...
متن کاملActivation of plasminogen by trypsin and plasmin.
teolytic enzyme plasmin (fibrinolysin) is supposed to be present in normal blood plasma in an inactive form, called plasminogen (proplasmin). Anxiety, strenuous exercise, hemorrhage, burn , t rauma (‘ ‘tourniquet shock’ ‘) and epinephrine admmistration have heels found to produce increased fibrinolytic activity (plasmin formation) in the blood. 3 The physiologic mechanism of activation of propl...
متن کاملE-Aminocaproic Acid: an Inhibitor of Plasminogen Activation*
Human and animal sera contain a globulin, plasminogen, which in the presence of activators is rapidly converted to plasmin, a proteolytic enzyme active at neutral hydrogen ion concentrations. Activators specific for plasminogen include streptokinase and staphylokinase of bacterial origin, urokinase and plasma activator found in body fluids, and fibrinokinase derived from tissues. Trypsin, an ac...
متن کاملxi-Aminocaproic acid: an inhibitor of plasminogen activation.
Human and animal sera contain a globulin, plasminogen, which in the presence of activators is rapidly converted to plasmin, a proteolytic enzyme active at neutral hydrogen ion concentrations. Activators specific for plasminogen include streptokinase and staphylokinase of bacterial origin, urokinase and plasma activator found in body fluids, and fibrinokinase derived from tissues. Trypsin, an ac...
متن کاملMechanism of formation of bovine plasminogen activator from human plasmin.
It has been shown that the activation of bovine plasminogen by streptokinase plus a trace amount of human globulin involves a two-stage activation process (1, 2). Ablondi and Hagan (3) proposed that the proactivator of bovine plasminogen was identical with human plasminogen, which became activator by forming complexes with streptokinase. Kline and Fishman (4) using a lysine methyl ester assay d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 1959
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.8.219